[ Center of Drug Absorption and Transport ]

Kompetenzzentrum der Ernst-Moritz-Arndt-Universität Greifswald

Zeitschriftenbeiträge, Fachartikel

Publikationen

 Zeitschriftenbeiträge:

Nassif et al., Radiology 2012 (under revision),  Visualization of hepatic uptake transporter function in healthy subjects using Gd-EOB-DTPA enhanced magnetic resonance imaging.

Meyer zu Schwabedissen et al., Clin Pharmacol Ther 2012 (accepted), Compartment specific gene regulation of the CA-inducer efavirenz in vivo.

Jia et al., J Chromatogr B Analyt Technol Biomed Life Sci 2012 (accepted), A LC-MS/MS method to evaluate the hepatic uptake of the liver-specific magnetic resonance imaging contrast agent gadoxetate (Gd-EOB-DTPA) in vitro and in humans.

Salje et al., Basic Clin Pharmacol Toxicol 2012 (accepted), Effects of rifampicin, dexamethasone, St. John's Wort and thyroxine on maternal and fetal expression of Abcb1 and organ distribution of talinolol in pregnant rats.

Oswald et al., Clin Pharmacol Ther 2012 (accepted), Impact of efavirenz on intestinal metabolism and transport: Insights from an interaction study with ezetimibe in healthy volunteers. 

Peters et al. Drug Metab Dispos 2012, 40(3):522-8. Clarithromycin is absorbed by an intestinal uptake mechanism that is sensitive to major inhibition by rifampicin: results of a short-term drug interaction study in foals.

Haznar-Garbacz et al., AAPS PharmSciTech. 2011, 12(4):1183-5. An oral-controlled release drug delivery system for liquid and semisolid drug formulations.

Oswald et al., Development of Therapeutic Agents Handbook 2011, 723-42. Ezetimibe and Cholesterol Absorption.

Oswald et al., J Pharm Biomed Anal 2011, 56(5):1079-84. Quantitative determination of methylnaltrexone in human serum using liquid chromatography-tandem mass spectrometry.

Mähler et al., Pharmacogenet Genomics 2011 [Epub ahead of print]. Kidney-specific deletion of multidrug resistance-related protein 2 does not aggravate acute cyclosporine A nephrotoxicity in rats.

Block et al., Nano Lett 2011, 11(9):3587-3592. Direct Visualization and Identification of Biofunctionalized Nanoparticles using a Magnetic Atomic Force Microscope.

Peters et al., Drug Metab Dispos 2011, 39(9):1643-9. Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.

König et al., Drug Metab Dispos 2011, 39(6):1097-102. Role of anion-transporting polypeptides for cellular mesalzine (5-amino salicylic acid) uptake.

Budde et al., J Pharm Sci 2011, 100(9):3951-8. Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression. 

Oswald et al., J Pharm Biomed Anal 2011, 55(1):194-201. LC-MS/MS method for the simultaneous determination of clarithromycin, rifampicin and their main metabolites in horse plasma, epithelial lining fluid and broncho-alveolar cells.

Oswald et al., Clin Pharmacol Ther 2011, 89(4):524-8. Drug interactions between the immunosuppressant tacrolimus and the cholesterol-absorption inhibitor ezetimibe in healthy volunteers.

Oswald et al., Handb Exp Pharmacol 2011, 201:403-47. In Vivo Probes of Drug Transport: Commonly Used Probe Drugs to Assess Function of Intestinal P-glycoprotein (ABCB1) in Humans.

Nambaru et al., Drug Metab Dispos 2010, 39(1):132-9. Drug efflux transporter MRP5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.

Mandery et al., Biochem Pharmacol 2010, 80(11):1746-53. Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1.

Garbacz et al., Expert Opin Drug Deliv 2010, 7(11):1251-61. A biorelevant dissolution stress test device - background and experiences.

Hanke et al., Eur J Pharm Biopharm 2010 Oct;76(2):260-8. Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 (p-glycoprotein) and ABCC2 (MRP2).

Niessen et al., Pharmacogenet Genomics. 2010, 20(6):396-400. Expression of ABC-type transport proteins in human platelets.

Leonhardt et al., Drug Metab Dispos 2010, 38(7):1024-8. Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA, role of human organic anion transporters.

Oswald et al., Clin Pharmacol Ther 2010, 87(6):663-7. Pharmacokinetic and Pharmacodynamic Interactions Between the Immunosuppressant Sirolimus and the Lipid-Lowering Drug Ezetimibe in Healthy Volunteers. 

Venner, Peters et al., Naunyn Schmiedebergs Arch Pharmacol 2010, 381(2):161-9. Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals.  

Oswald et al., J Pharm Sci 2010, 99(1):422-9. Synergistic influence of Abcb1 and Abcc2 on disposition and sterol-lowering effects of ezetimibe in rats.

 Garbacz et al., Drug Dev Ind Pharm. 2010, 36(5):518-30. Investigation of dissolution behavior of diclofenac sodium extended release formulations under standard and biorelevant test conditions.

Garbacz et al.,  Eur J Pharm Sci 2009, 38(2):147-55. Compasison of dissolution profiles obtained from nifedipine extended release once a day products using different dissolution test apparatuses.

Garbacz, Adam et al., Deutsche Apotheker Zeitung 2009, 149(27):70-77. Nifedipin-Retardtabletten mit unterschiedlicher Galenik

Niessen et al., Drug Metab Dispos 2009, 37(5):1129-37.  Human platelets express OATP2B1, an uptake transporter for atorvastatin.

Garbacz et al., Eur J Pharm Biopharm 2008, 70(2):421-8. Irregular Absorption Profiles Observed From Diclofenac Extended Release Tablets Can Be Predicted Using A Dissolution Test Apparatus That Mimics In Vivo Physical Stresses.

Oswald et al., Pharmacogenetics and Genomics 2008, 18(7):559-68. Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1.

Döring et al., Nature Genetics 2008, 40(4):430-6. SLC2A9 influences uric acid concentrations with pronounced sex-specific effects.

Poster / Vorträge:

Keiser et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting,  March 12-17 2012, National Harbor, USA: Affinity of the bladder spasmolytic trospium chloride to drug transport proteins (Poster)

Drozdzik et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting,  March 12-17 2012, National Harbor, USA: Expression of drug metabolizing enzymes and transporter proteins along the entire human gastrointestinal tract (Vortrag)

Nassif et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, March 12-17 2012, National Harbor, USA: Efficacy of oral and subcutaneous methylnaltrexone to prevent loperamide-induced constipation in healthy subjects (Poster)

Nassif et al., 13. Jahreskongress für Klinische Pharmakologie, Oktober 20-22 2011, Zürich, Switzerland: Loperamide-induced constipation in healthy subjects – an experimental model to evaluate the anti-constipation effect of methylnaltrexone (Poster)

Peters et al., 13. Jahreskongress für Klinische Pharmakologie, Oktober 20-22 2011, Zürich, Switzerland: Expression of drug transport proteins in peripheral blood monocytes, bronchoepithelial cells, nasal epithelial cells and alveolar macrophages in healthy volunteers (Poster)

Engel et al., 13. Jahreskongress für Klinische Pharmakologie, Oktober 20-22 2011, Zürich, Switzerland: Influence of solubilizing agents on the function of human organic anion uptake transport proteins (Poster)

Keiser et al., 13. Jahreskongress für Klinische Pharmakologie, Oktober 20-22 2011, Zürich, Switzerland: The role of OATP1A2, OCT1 and ABCB1 on trospium chloride transport in vitro (Poster)

Hubeny et al., RNAi & miRNA Europe, September 08-09 2011, München: Gestational changes in microRNA expression in human placenta (Poster)

Keiser et al., BioMedical Transporters 2011, August 07-11, Grindelwald, Switzerland: Influence of solubilizing agents on the function of human organic anion uptake transporter polypeptides (Poster)

Glöckl et al., 38th Annual Meeting & Exposition of the Controlled Release Society, July 30 - August 3, 2011, National Harbor, Maryland, USA: A formulation approach to improve the in vivo performance of furosemide (Poster)

Nassif et al., 10th EACPT Congress, 26-29 June 2011, Budapest, Hungary: Loperamide-Induced Constipation in Healthy Subjects - A Model to Evaluate the Laxative Effect of Methylnaltrexone (Poster)

Jia et al., 10th EACPT Congress, 26-29 June 2011, Budapest, Hungary: Gd-Eob-Dtpa Is A Substrate of Abcc2, Oatp1B1 and Oatp1B3 and Their Genetic Variants (Vortrag)

Keiser et al.,13. Herrenalber Transportertage, May 30-June 1 2011, Bad Herrenalb: Trospium chloride is a substrate of OATP1A2 and OCT1 (Poster)

Oswald et al., Proteomic Forum 2011, April 03-07 2011, Berlin: Comparison of absolute protein quantification by Western blot and MRM-based mass spectrometric analysis (Poster)

Engel et al., Doktorandentagung der DPhG, March 30-April 02 2011, Heringsdorf: Influence of solubilizing agents on the function of uptake transport proteins in vitro and in vivo

Peters et al., Doktorandentagung der DPhG, March 30-April 02 2011, Heringsdorf: Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals (Poster)

Engel et al., Controlled Release Society-Tagung, March 15-16 2011, Jena: Influence of solubilizing agents on the function of human organic anion uptake transport proteins (Poster)

Oswald et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, March 02-05 2011, Dallas, USA: Influence of Roux-en-Y gastric bypass surgery on the disposition of paracetamol, talinolol and amoxicillin in obese patients (Poster)

Naddaf et al., 12. Jahreskongress für Klinische Pharmakologie, November 04-06 2010, Würzburg: In vitro effects of intestinal and hepatic uptake transporters on talinolol uptake (Poster)

Nassif et al., 12. Jahreskongress für Klinische Pharmakologie, November 04-06 2010, Würzburg: Hepatic Uptake and Pharmacokinetics of the MRI Contrast Agent Gadoxetate in Healthy Subjects, Role of OATP1B1, OATP1B3 and ABCC2

Peters et al., Jahrestagung der Deutschen Pharmazeutischen Gesellschaft 2010, October 04-07 2010, Braunschweig: Influence of Roux-en-Y gastric bypass surgery on the pharmacokinetics of paracetamol, talinolol and amoxicillin in obese patients (Vortrag)

Oswald et al., Jahrestagung der Deutschen Pharmazeutischen Gesellschaft 2010, October 04-07 2010, Braunschweig: Impact of efavirenz on intestinal and hepatic metabolism and transport: Interaction study with ezetimibe in healthy volunteers (Vortrag)

Glöckl et al., Jahrestagung der Deutschen Pharmazeutischen Gesellschaft 2010, October 04-07 2010, Braunschweig: Development of a gastro-retentive extended release formulation of furosemide (Poster)

Koenen et al., 9th International Meeting of the Society for the Study of Xenobiotics, September 04-08 2010, Istanbul, Turkey: Effect of Steroids on Transport Characteristics of the Organic Anion Transporting Polypeptides (OATP) 1A2, 1B1, 1B3 and 2B1 (Poster)

Grube et al., 9th International Meeting of the Society for the Study of Xenobiotics, September 04-08 2010, Istanbul, Turkey: Characterization of Placental SLC22A4 (OCTN1) and SLC22A5 (OCTN2) Expression: Influence of Genotype and Gestation Age (Poster)

Oswald et al., 9th International Meeting of the Society for the Study of Xenobiotics, September 04-08 2010, Istanbul, Turkey: Efavirenz induces hepatic and peripheral but not intestinal target genes of CAR (Poster)

Peters et al., 9th International Meeting of the Society for the Study of Xenobiotics, September 04-08 2010, Istanbul, Turkey: Influence of Roux-en-Y gastric bypass surgery on the pharmacokinetics of paracetamol, talinolol and amoxicillin in obese patients (Poster)

Oswald et al., 16th World Congress on Basic and Clinical Pharmacology, July 17-23 2010, Copenhagen, Denmark: Influence of efavirenz on the disposition and lipid-lowering effects of ezetimibe in healthy subjects (Poster)

Peters et al., 16th World Congress on Basic and Clinical Pharmacology, July 17-23 2010, Copenhagen, Denmark: Influence of rifampicin on pulmonary expression of ABCB1 and ABCC2 and on distribution of clarithromycin into epithelial lining fluid and broncho-alveolar cells of foals (Poster)

Kühn et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, March 17-20 2010, Atlanta, USA: Influence of OATP1B1, OATP1B3 and ABCC2 on the hepatic uptake of Primovist in healthy volunteers (Vortrag) 

Schwabedissen et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, March 17-20 2010, Atlanta, USA: Efavirenz induces expression of CAR target genes in hman PBMCs (Poster) 

Oswald et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, March 17-20 2010, Atlanta, USA: Drug interactions between ezetimibe and efavirenz in healthy subjects (Vortrag) 

Glöckl et al., 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 08-11 2010, Valletta, Malta: Development of a gastro-retentive extended release formulation of furosemide. (Vortrag)

Hanke et al., 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 08-11 2010, Valletta, Malta: Development of a pulsatile dosage form containing dipyrone

Peters et al., Jahrestagung der Deutschen Pharmazeutischen Gesellschaft 2009, September 28 – October 1 2009, Jena: Influence of rifampicin on the disposition of clarithromycin and the distribution into epithelial lining fluid and broncho-alveolar cells of foals (Vortrag)

Leonhardt et al., BioMedical Transporters 2009, 9-13 August 2009, Thun, Switzerland: Meglumine iotroxate (Biliscopin) interacts with the human hepatic uptake transport protein OATP1B3 in vitro (Poster)

Peters et al., BioMedical Transporters 2009, 9-13 August 2009, Thun, Switzerland: Influence of rifampicin on pulmonary pharmacokinetics of clarithromycin and expression of ABCB1 and ABCC2 in broncho-alveolare cells of foals (Poster)  

Keiser et al., BioMedical Transporters 2009, 9-13 August 2009, Thun, Switzerland: Gd-EOB-DTPA is a substrate of the liver specific organic anion transporters OATP1B1 and OATP1B3 (Poster)

Hanke et al., 36th Annual Meeting & Exposition of the Controlled Release Society, July 19-23 2009, Kopenhagen, Denmark: Pharmaceutical surfactants interact differently with the human efflux transporters ABCB1 and ABCC2 (Vortrag) 

Glöckl et al., 36th Annual Meeting & Exposition of the Controlled Release Society, July 19-23 2009, Kopenhagen, Denmark: Yeast containing minitablets for modified drug release (Poster)  

Leonhardt et al., 11th European Meeting of the Society for the Study of Xenobiotics, May 17-20 2009, Lisbon, Portugal: In vitro uptake of the MRI contrast agent gadoxetate (Gd-EOB-DTPA) by the human uptake carrier OATP1B1 (Poster)

Scheuch et al. FASEB EB Meeting, April 18-22 2009, New Orleans, USA: Metabolism of the analgesic flupirtin in man (Poster)

Oswald et al., American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, March 18-21 2009, Washington, USA: Lack of significant drug interactions between ezetimibe and tacrolimus in healthy subjects (Poster)

Oswald et al., 10. Jahreskongress für Klinische Pharmakologie, November 6-8 2008, Berlin, Germany: Lack of significant drug interactions between ezetimibe and tacrolimus in healthy subjects (Poster)

Rimmbach et al., 10. Jahreskongress für Klinische Pharmakologie, November 6-8 2008, Berlin, Germany: Genetic variants in the insulin-induced gene 2 (INSIG2) and the risk for obesity – efffects of a novel promoter variant (Poster)

Scheuch et al., 10. Jahreskongress für Klinische Pharmakologie, November 6-8 2008, Berlin, Germany: The role of UGT-isoforms in metabolism of flupirtin (Poster)

Glöckl et al., Benediktbeurer Rundgespräche 2008, September 24-26 2008, Benediktbeuern, Germany: Magnetische Nanopartikel: Perspektiven und Hindernisse auf dem Weg zum Arzneimittel oder Medizinprodukt (Vortrag)

Leonhardt et al., 35th Annual Meeting & Exposition of the Controlled Release Society, July 12-16 2008, New York USA: Influence of pharmaceutical surfactants as Modulators of the efflux transporter P-glycoprotein (Poster)

Glöckl  et al., 7th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, May 21-24 2008, Vancouver, Canada: Magnetic Drug Targeting to the Lung: Preliminary In vitro Investigations (Poster)

Oswald et al., 10th European Meeting of the Society for the Study of Xenobiotics, May 18-21 2008, Vienna, Austria: Lack of significant parmacokinetic interactions between the ABCB1 substrates sirolimus and ezetimibe in healthy subjects (Poster)

Siegmund et al. 10th European Meeting of the Society for the Study of Xenobiotics, May 18-21 2008, Vienna, Austria: Clinical-Pharmacological Approaches to Confirm the Role of Intestinal Metabolism and Transport in Disposition of Drugs (Vortrag)

Grube et al., 10th European Meeting of the Society for the Study of Xenobiotics, May 18-21 2008, Vienna, Austria: Expression of drug-uptake transporters in normal and dilative hearts (Poster)

Koeck et al., 10th European Meeting of the Society for the Study of Xenobiotics, May 18-21 2008, Vienna, Austria: Regulation of OATP2B1 trafficking by protein kinase C (Poster)

Adam et al., 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 7-10 2008, Barcelona, Spain: Interaction of pharmaceutical surfactants with the human efflux transporters P-glycoprotein and MRP2 (Vortrag)

Oswald et al, American Society of Clinical Pharmacology and Therapeutics - Annual Meeting, April 2-5 2008, Orlando, USA: Drug interactions between the immunosuppressant sirolimus and the cholesterol-lowering agent ezetimibe in healthy subjects (Poster)

Keiser et al., 2nd FEBS Special Meeting on ABC Proteins, March 1-8 2008, Innsbruck, Austria: Rifampicin regulates Abcb1 and Abcc2 and influences accumulation of the macrolide antibiotic tulathromycin in broncho-alveolar cells of healthy foals (Poster)

Oswald et al., 9. Jahreskongress für Klinische Pharmakologie, November 1-3 2007, Kiel, Germany: Disposition of sirolimus is not influenced by comedication of ezetimibe in healthy subjects (Poster)

Scheuch et al., 9. Jahreskongress für Klinische Pharmakologie, November 1-3 2007, Kiel, Germany: Metabolic disposition of flupirtin in man assessed by LC-MS and HRMS (Poster)

Oswald et al., 8th International Meeting of the Society for the Study of Xenobiotics, October 9-12 2007, Sendai, Japan: Pregnancy-related changes, fetal development and postnatal maturation of ABCB1 and ABCC2 in rats (Poster)

Grube et al., 8th Inter